Search for:
  • Home/
    • Month: August 2018
League Of Legends

Why Should You Play PBE League Of Legends?

Every game that’s being developed or is in a state of constant improvement has some kind of a test server. That’s where the developers present the newest features they want to add to the game and analyze the reaction of their player base to the changes implemented and the way they affect different aspects of the game, and different technical problems that occur during the implementation of these features.

League of Legends is one of the games that use such test servers. PBE (or Public Beta Environment) is available for players to check out the newest features the game might gain. However, should you actually join or would it be better to play a game on a regular server?

Pros and Cons of PBE

There are lots of great reasons for you to start a PBE account. The most common arguments are:

League Of Legends

  • You will be able to experience all the newest features first;
  • The account is set on the level 30 from the get-go, so you can experience the game to its fullest;
  • Every day you get a certain amount of in-game currency, so you don’t have to worry about the grind to unlock new champions or skins.

However, playing on the test server has some disadvantages. Among the most frequent problems are:

  • The rush of players after the implementation of new features can cause lag;
  • Matchmaking is not always as reliable as during the game on the main server;
  • If you’re not from America, you can experience a high ping because of the location of the test server.

How To Get A PBE Account In LoL?

If you don’t know how to get PBE account LoL offers a couple ways to do it. Firstly, you can request such an account for free from the Riot Games website. However, it will require for your main League of Legends account to fit some criteria. If your account doesn’t fit them or you want to start playing PBE without a direct link to your main account, you can always purchase an account to start playing on a test server right away, without any background check. So, make your choice and start trying out the newest LoL features right now!

Final Thoughts

Playing in PBE has both pros and cons, and it’s up to you to decide whether experiencing the latest additions to the game is more important than the occasional lag. Playing on main servers offers a pretty full experience, but if you want to get something more unique out of this game, start your own PBE account right now!

artemisia annua cancer dosage

Use of Artemisia Annua L For Treatment of Malaria

Coartem 20/120 is a first-line treatment approved by the WHO for uncomplicated malaria in most endemic countries, based on a dose of 3 tablets for 3-day adults. Each tablet measuring 140 milligrams (mg) contains 20 mg of Artemether and 120 mg of lumefantrine. Coartem 20/120 is also known as ACT (artemisinin combination therapy), since artemether is obtained from artimizinin, which, in turn, is extracted from Artemisia Annua L. and combined with lumefantrine (synthetic antimalarial). TCAs are the primary treatment for malaria falciparum plasmodium and the most serious in sub-Saharan Africa. All the old synthetic antimalarial drugs are currently ineffective. As such, WHO encouraged the adaptation of ACT as first-line treatment for uncomplicated malaria.

Depending on the method used, the recovery of the pharmaceutical grade sweet wormwood health benefits from the crude artemisinin class is approximately 30%. Therefore, 480 mg of artemetra in Coartem 20/120 will require 1440 mg of artemisinin, which is evenly distributed in the 24 tablets required for complete treatment.

 

Historical antimalarialsartemisia annua cancer dosage

At this point, it may be useful to establish the prescribed 1440 mg or 1.44 grams of artemisinin, necessary for the treatment of the historical use of Artemisia, when its leaves are boiled in water and consumed as a therapeutic tea.

The typical shrub Artemisia Annua L. has a height of 1.5 to 2 meters and is almost round (significantly less in China). The content of dry leaves varies, but on average a shrub can produce 250 g. The typical artemisinin content in Artemisia, which is grown in China and Vietnam, is 0.06 to 0.1 percent, and the solvent extraction efficiency of hexane is 60 to 80 percent.

calculations

  1. Dry leaf. Content of an Artemisia board = 250 grams
  2. The average artemisinin content at 0.08% * 250 = 2.0 grams
  3. Extraction efficiency + purification = 0.7 or 70%
  4. Artemisinin output of a buffer 2.0 * .7 = 1.4 grams
  5. Requirements for artemisinin in ACT treatment = 1.44 grams
  6. Percentage of hives needed for treatment 1.44 * 100 / 1.4 = 100%

Conclusion

Given the above characteristics, the extraction of 1.44 grams of Artemisinin would require a little more than the totality of Lumus Artemisia L annual. Therefore, historically in China, the patient would require that almost all of the shrub be crushed or boiled for effective treatment, suggesting that In ACT, which are the main modern antimalarial drugs, a much higher artemisia annua cancer dosage than required is used.